{"id":17360,"date":"2025-09-11T03:57:43","date_gmt":"2025-09-11T03:57:43","guid":{"rendered":"https:\/\/ivolabs.com\/?post_type=product&p=17360"},"modified":"2026-11-05T15:22:25","modified_gmt":"2026-11-05T15:22:25","slug":"fluoprazolam-eu","status":"publish","type":"product","link":"https:\/\/ivolabs.com\/fi\/tuote\/fluoprazolam-eu\/","title":{"rendered":"Fluoprazolam Freebase EU"},"content":{"rendered":"

Fluoprazolam \u2013 Nitro-Benzimidazodiazepine Research Standard<\/strong><\/h3>\n
\n

\ud83d\udd2c Overview<\/strong><\/h3>\n

Fluoprazolam<\/strong> is a synthetic benzimidazo[1,2-a][1,4]diazepine<\/strong> derivative distinguished by its fluorophenyl<\/strong>, nitro<\/strong>, and methylpiperazinylmethylene<\/strong> substitutions. This unique design sets it apart from classical triazolo- and diazepine benzodiazepines.<\/p>\n

First appearing in the late 2010s, Fluoprazolam has since gained recognition in the fields of forensic toxicology<\/strong> and receptor pharmacology research<\/strong>, owing to its exceptionally high potency<\/strong> and long duration of action.<\/p>\n

\n

\u269b\ufe0f Chemical Identity<\/strong><\/h3>\n
    \n
  • \n

    IUPAC<\/strong>: (Z)-6-(2-fluorophenyl)-2-((4-methylpiperazin-1-yl)methylene)-8-nitro-4H-benzo[f]imidazo[1,2-a][1,4]diazepin-1-one<\/em><\/p>\n<\/li>\n

  • \n

    Molecular Formula<\/strong>: C\u2082\u2082H\u2082\u2081FN\u2086O\u2083<\/p>\n<\/li>\n

  • \n

    Molecular Weight<\/strong>: ~436.44 g\/mol<\/p>\n<\/li>\n

  • \n

    Chemical Class<\/strong>: Benzimidazodiazepine (nitro-substituted)<\/p>\n<\/li>\n

  • \n

    Appearance<\/strong>: Off-white crystalline solid (typically supplied as hydrochloride salt)<\/p>\n<\/li>\n<\/ul>\n

    \n

    \u2699\ufe0f Pharmacology<\/strong><\/h3>\n

    Fluoprazolam is presumed to act as a positive allosteric modulator at GABA<sub>A<\/sub> receptors<\/strong>, enhancing the inhibitory effect of gamma-aminobutyric acid (GABA).<\/p>\n

    Expected effects (based on class data):<\/strong><\/p>\n

      \n
    • \n

      Sedation and sleep induction<\/p>\n<\/li>\n

    • \n

      Strong anxiolysis<\/p>\n<\/li>\n

    • \n

      Anticonvulsant activity<\/p>\n<\/li>\n

    • \n

      Profound muscle relaxation<\/p>\n<\/li>\n

    • \n

      Memory impairment at high exposures<\/p>\n<\/li>\n<\/ul>\n

      The presence of a nitro group<\/strong> and fluorophenyl substitution<\/strong> typically indicates high receptor affinity<\/strong>, while the piperazinylmethylene side chain<\/strong> may alter metabolic stability and receptor subtype selectivity.<\/p>\n

      \n

      \ud83d\udcc8 Pharmacokinetics<\/strong> (based on structural class)<\/em><\/h3>\n
        \n
      • \n

        Onset (oral):<\/strong> 20\u201360 minutes<\/p>\n<\/li>\n

      • \n

        Duration:<\/strong> 12\u201318 hours (residual sedation possible beyond 24h)<\/p>\n<\/li>\n

      • \n

        Metabolism:<\/strong> Hepatic (likely CYP3A4 and reductive pathways for the nitro group)<\/p>\n<\/li>\n

      • \n

        Excretion:<\/strong> Renal as metabolites<\/p>\n<\/li>\n<\/ul>\n

        This pharmacokinetic profile indicates a long-acting benzodiazepine<\/strong>, with significant potential for accumulation if repeatedly dosed.<\/p>\n

        \n

        \u26a0\ufe0f Toxicological Concerns<\/strong><\/h3>\n

        Fluoprazolam is highly potent<\/strong> \u2014 active in sub-milligram (microgram) amounts<\/strong>. Reported issues in forensic casework include:<\/p>\n

          \n
        • \n

          Blackouts<\/strong> and severe anterograde amnesia<\/p>\n<\/li>\n

        • \n

          Respiratory depression<\/strong>, especially with alcohol\/opioids<\/p>\n<\/li>\n

        • \n

          Loss of consciousness<\/strong> and prolonged sedation<\/p>\n<\/li>\n

        • \n

          Risk of dependence and withdrawal<\/strong> similar to other benzodiazepines<\/p>\n<\/li>\n<\/ul>\n

          The margin between effective and toxic dose may be narrow<\/strong>, making precise laboratory handling critical.<\/p>\n

          \n

          \u2757 Harm Reduction & Lab Safety<\/strong><\/h3>\n
            \n
          • \n

            Always use mg-precision or volumetric dilution techniques<\/strong><\/p>\n<\/li>\n

          • \n

            Avoid cross-contamination in shared lab equipment<\/p>\n<\/li>\n

          • \n

            Store in a controlled, dark, dry environment<\/strong><\/p>\n<\/li>\n

          • \n

            Restrict access to trained laboratory staff only<\/p>\n<\/li>\n<\/ul>\n

            \n

            \ud83d\udd2c Research & Forensic Applications<\/strong><\/h3>\n

            Fluoprazolam is commonly included in:<\/p>\n

              \n
            • \n

              LC\u2013MS\/MS and GC\u2013MS reference libraries<\/strong><\/p>\n<\/li>\n

            • \n

              Forensic toxicology panels<\/strong> investigating unexplained sedation or impaired driving<\/p>\n<\/li>\n

            • \n

              Receptor binding studies<\/strong> exploring nitro- and piperazine-substituted diazepines<\/p>\n<\/li>\n

            • \n

              Comparative SAR analysis<\/strong> alongside classical benzodiazepines<\/p>\n<\/li>\n<\/ul>\n

              \n

              \ud83c\udf0d Legal Status<\/strong><\/h3>\n
                \n
              • \n

                Controlled<\/strong> in most jurisdictions (USA Schedule IV, UK Class C, EU under benzodiazepine or NPS bans, Australia, Canada, Japan).<\/p>\n<\/li>\n

              • \n

                In countries without specific scheduling, may be covered by analog or generic NPS laws<\/strong>.<\/p>\n<\/li>\n<\/ul>\n

                \n

                \ud83d\udccc Summary<\/strong><\/h3>\n

                Fluoprazolam<\/strong> is an extremely potent nitro-benzimidazodiazepine<\/strong> with unique structural features. Its long duration, strong sedative activity, and narrow therapeutic window make it a compound of great interest to toxicologists, forensic chemists, and neuropharmacology researchers<\/strong>, but also one requiring rigorous safety controls<\/strong> in all research applications.<\/p>\n","protected":false},"excerpt":{"rendered":"

                Fluoprazolam \u2013 Ultra-Potent Benzimidazodiazepine<\/h2>\n

                Fluoprazolam<\/strong> is a nitro-substituted benzimidazodiazepine featuring a fluorophenyl group and a piperazinylmethylene side chain. Known for its extreme potency, it enhances GABAA<\/sub> activity and produces intense sedative, anxiolytic, and amnestic effects in research models.<\/p>\n

                  \n
                • IUPAC: (Z)-6-(2-fluorophenyl)-2-((4-methylpiperazin-1-yl)methylene)-8-nitro-4H-benzo[f]imidazo[1,2-a][1,4]diazepin-1-one<\/li>\n
                • Duration: 12\u201318 hours<\/li>\n
                • Active in sub-milligram range<\/li>\n
                • Intended for laboratory and forensic research use only<\/li>\n<\/ul>\n

                  Not for human consumption. Handle with extreme precision and safety.<\/em><\/p>\n

                  This like all the products from EU RC are shipped by express mail without tracking number, <\/strong>
                  \nto European countries ONLY.<\/strong><\/p>\n","protected":false},"featured_media":17366,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[180,164],"product_tag":[1137,1146,1148,1152,1149,1145,1153,1140,1144,1154,1143,1141,1147,1138,1151,1135,1136,1139,1142,1150],"class_list":["post-17360","product","type-product","status-publish","has-post-thumbnail","product_cat-benzo-opioid","product_cat-europe-stock","product_tag-benzimidazo-diazepine","product_tag-benzodiazepine-analog-toxicology","product_tag-benzodiazepine-casework","product_tag-benzodiazepine-overdose-research","product_tag-benzodiazepine-pharmacology","product_tag-benzodiazepine-receptor-binding","product_tag-benzodiazepine-reference-standard","product_tag-benzodiazepine-research-chemical","product_tag-benzodiazepine-sar","product_tag-cns-depressant-analog","product_tag-designer-benzodiazepine","product_tag-forensic-benzo-standard","product_tag-forensic-toxicology-compound","product_tag-gaba-a-modulator","product_tag-lab-only-benzodiazepine","product_tag-luoprazolam","product_tag-nitro-benzimidazodiazepine","product_tag-potent-benzodiazepine-analog","product_tag-sedative-hypnotic-research","product_tag-ultra-potent-benzo","first","instock","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/ivolabs.com\/fi\/wp-json\/wp\/v2\/product\/17360","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ivolabs.com\/fi\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/ivolabs.com\/fi\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/ivolabs.com\/fi\/wp-json\/wp\/v2\/comments?post=17360"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ivolabs.com\/fi\/wp-json\/wp\/v2\/media\/17366"}],"wp:attachment":[{"href":"https:\/\/ivolabs.com\/fi\/wp-json\/wp\/v2\/media?parent=17360"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/ivolabs.com\/fi\/wp-json\/wp\/v2\/product_brand?post=17360"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/ivolabs.com\/fi\/wp-json\/wp\/v2\/product_cat?post=17360"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/ivolabs.com\/fi\/wp-json\/wp\/v2\/product_tag?post=17360"}],"curies":[{"name":"hp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}