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Warning: Sildenafil is not for human or veterinary use.
Cyclic guanosine monophosphate (cGMP) is the ubiquitous second messenger for G-protein coupled receptors activated by endogenous substances such as nitric oxide and atrial natriuretic peptide. It can be generated by soluble guanylyl cyclase in response to binding of nitric oxide and degraded via members of the phosphodiesterase (PDE) protein family. Sildenafil, formulated for human use and marketed under the trade name Viagra™, is a potent cGMP-specific phosphodiesterase that is highly selective for PDE5. It inhibits PDE5 activity in isolated rabbit platelets with an IC50 value of 3.6 nM (3 nM in human corpus cavernosum) compared to inhibition of PDE1 and PDE3 activities (IC50s = 0.26 and 65 μM, respectively). Inhibition of type 5 PDE enhances the relaxation of smooth muscle in a range of vascular tissues by prolonging the nitric oxide/cGMP-mediated activation of cGMP-dependent protein kinase. While most notable for its use in the treatment of erectile dysfunction, sildenafil’s vasorelaxant properties have also been used to control vascular tone in pulmonary arterial hypertension and high-altitude pulmonary edema associated with altitude sickness.
Buy Sildenafil for research purposes. Sildenafil produced under German supervision.
|trivial name||Viagra, Sildenafil|
- This Item: Sildenafil EUR As low as €5.00
- MODAFINIL Tablets 200mg €0.00
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