Melanotan 1
€260.00
Melanotan 1 (Afamelanotide) is a synthetic linear analogue of alpha-melanocyte-stimulating hormone (α-MSH) with high selectivity for the melanocortin-1 receptor (MC1R). Clinically investigated as Scenesse®, it is a well-characterized melanogenic peptide supplied as lyophilized powder with ≥98% purity (HPLC-verified).
Mechanism of Action
Melanotan 1 binds selectively to MC1R on melanocytes, activating the cAMP/PKA signaling cascade and stimulating eumelanin synthesis via upregulation of tyrosinase, TRP-1, and TRP-2. Its high MC1R selectivity results in melanogenesis without significant off-target melanocortin receptor activity.
Research Findings & Benefits Under Investigation
- Melanogenesis: Stimulates eumelanin (brown/black pigment) production in melanocytes independently of UV exposure, producing a sustained tan-like pigmentation.
- Photoprotection: Increases minimal erythemal dose (MED) and reduces UV-induced DNA damage (cyclobutane pyrimidine dimers) in photoprotection research models.
- Erythropoietic Protoporphyria (EPP): Clinically approved for EPP, demonstrating significant increases in pain-free light exposure time with a favorable safety profile in Phase III trials.
- Anti-Inflammatory Activity: Modulates cutaneous inflammation through MC1R-mediated suppression of NF-κB signaling, with reduced pro-inflammatory cytokine expression.
- DNA Repair: Enhances nucleotide excision repair capacity in UV-exposed keratinocytes through MC1R-dependent pathways.
Research Applications
- Melanocortin receptor pharmacology and biased agonism
- Melanogenesis and pigmentation disorders
- UV-induced DNA damage and photoprotection assays
- Porphyria and photosensitivity disorder models
- MC1R-mediated anti-inflammatory signaling
Product Specifications
- Purity: ≥98% (HPLC)
- Form: Lyophilized powder
- Molecular Weight: ~1,646 Da
- Solubility: Reconstitute in sterile bacteriostatic water
Storage & Handling
- Store lyophilized peptide at -20°C, protected from light and moisture.
- After reconstitution, aliquot and store at -20°C. Avoid repeated freeze-thaw cycles.
Disclaimer: This product is intended exclusively for laboratory and research purposes. It is not a drug, dietary supplement, or food product. Not for human or veterinary diagnostic, therapeutic, or prophylactic use.
What the Internet Says
This is what online communities discuss. Not medical advice — for laboratory research use only.
Community Buzz
Melanotan 1 is “the clean tan peptide” — the older, gentler sibling of MT-2. Users who choose MT-1 over MT-2 do so for one reason: significantly fewer side effects. No spontaneous erections, no libido spike, less nausea, less flushing — just a gradual, natural-looking tan that builds over weeks. The community considers it ideal for fair-skinned users and anyone who wants the photoprotective benefits without the MT-2 side-effect roller coaster. The tan develops more slowly but looks more natural — nobody will ask “are you on something?” It’s also approved as Scenesse (afamelanotide) for specific medical conditions, giving it more regulatory legitimacy than MT-2.
Why People Are Interested
- Natural-looking tan without the drama. Gradual color development without the MT-2 sides — no nausea, no libido issues, no flushing.
- Built-in UV protection. More melanin = natural photoprotection from sun damage.
- Better safety profile. Fewer side effects and more regulatory recognition than MT-2.
⚠️ Results develop more slowly than MT-2 — expect weeks, not days. Community protocols are experimental. This information is for awareness only.
| Dosage |
10mg*10vials |
|---|
Shipping & Delivery
All peptide products are shipped directly from our fulfillment center in China.
Delivery Time: 6 to 12 business days worldwide.
Tracking: A tracking number is provided via email once your order has been dispatched.
For any questions regarding your shipment, please contact our support team.
All peptide products are supplied as a lyophilized (freeze-dried) powder in sterile glass vials. Lyophilization preserves the peptide's structural integrity and biological activity during transport and storage. The powder must be reconstituted with an appropriate solvent before use in research protocols.
Recommended Solvent
For most peptide research applications, we recommend using Bacteriostatic Water (BAC) — sterile water containing 0.9% benzyl alcohol as a bacteriostatic agent. BAC water helps maintain sterility after reconstitution and is suitable for multi-dose research protocols.
Order Bacteriostatic Water (BAC) →
Reconstitution Protocol
- Prepare: Clean your work surface and ensure all materials (vial, BAC water, syringes) are handled in a sterile manner.
- Calculate: Determine the desired concentration by dividing the peptide mass (mg) by the volume of BAC water added (mL). For example, adding 2 mL of BAC water to a 5 mg vial yields a concentration of 2.5 mg/mL.
- Reconstitute: Using a sterile syringe, draw the calculated volume of BAC water. Insert the needle through the rubber stopper at an angle and slowly inject the solvent down the inner wall of the vial — avoid directing the stream directly onto the powder to prevent foaming.
- Dissolve: Gently swirl the vial (do not shake) until the powder is fully dissolved. Most peptides dissolve within 1-2 minutes. A clear, colorless solution indicates complete dissolution.
- Aliquot: For long-term use, transfer the reconstituted solution into sterile aliquots to avoid repeated freeze-thaw cycles of the original vial.
Post-Reconstitution Storage
- Store reconstituted peptide solution at 2-8°C for short-term use (up to 7 days).
- For extended storage, aliquot and freeze at -20°C. Avoid repeated freeze-thaw cycles.
- Always label aliquots with peptide name, concentration, date, and storage conditions.
Note: The optimal solvent and reconstitution protocol may vary depending on the specific peptide and research application. Researchers should consult peptide-specific literature for solubility guidance.
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