Humanin

Humanin is a 24-amino acid peptide encoded in the mitochondrial genome, first discovered in a screen of brain tissue from Alzheimer’s patients. It is a powerful cytoprotective peptide that shields cells from a wide range of insults — including amyloid beta toxicity, oxidative stress, and metabolic dysfunction. Supplied as lyophilized powder with ≥98% purity (HPLC-verified).

How It Works

Humanin binds to cell surface receptors and activates survival pathways, including STAT3 and ERK signaling, while blocking pro-death signals like Bax and Bid. It acts both inside and outside cells, protecting mitochondria from damage and preventing apoptosis (programmed cell death) triggered by toxins, inflammation, and metabolic stress.

Research Data

• Alzheimer’s protection: Humanin directly blocks amyloid beta toxicity — the protein that accumulates in Alzheimer’s — protecting neurons from death.
• Broad cytoprotection: Protects cells from diverse insults including oxidative stress, protein aggregation, mitochondrial toxins, and ischemia. This broad protection makes it relevant to multiple disease states.
• Diabetes: Improves insulin sensitivity and protects pancreatic beta cells from apoptosis — the cell death in the pancreas that drives type 1 and advanced type 2 diabetes.
• Cardiovascular: Protects heart cells during ischemia/reperfusion injury (heart attack) and reduces infarct size in animal models.
• Lifespan: Research shows Humanin levels decline with age. Restoring levels extends healthspan in animal models through improved mitochondrial function.
• Stroke: Neuroprotective effects in stroke models, with reduced brain damage when administered after an ischemic event.
• Biomarker: Humanin levels in blood are being investigated as a biomarker of healthy aging and mitochondrial function.

Research Applications

• Alzheimer’s and neurodegenerative disease research
• Mitochondrial biology and cytoprotection
• Diabetes and metabolic stress models
• Cardiovascular and ischemia research

Product Specifications

• Purity: ≥98% (HPLC)
• Form: Lyophilized powder
• Molecular Weight: ~2,657 Da
• Solubility: Reconstitute in sterile bacteriostatic water

Storage & Handling

• Store lyophilized peptide at -20°C, protected from light and moisture.
• After reconstitution, aliquot and store at -20°C. Avoid repeated freeze-thaw cycles.

Disclaimer: This product is intended exclusively for laboratory and research purposes. It is not a drug, dietary supplement, or food product. Not for human or veterinary use.

What the Internet Says

This is what online communities discuss about this compound. Not medical advice, not a recommendation — just what people are saying. For laboratory research use only.

Community Buzz

Humanin is “the mitochondrial bodyguard” — while MOTS-C supercharges mitochondria and SS-31 repairs them, Humanin protects them. Discovered in the brain tissue of Alzheimer’s patients, it’s a 24-amino acid peptide that shields cells from a wide range of threats: amyloid beta toxicity, oxidative stress, metabolic damage, even chemotherapy side effects. The community describes it as “turn on cell survival, turn off cell death.” It’s the third leg of the mitochondrial peptide trilogy (SS-31 repairs, Humanin protects, MOTS-C boosts). But it’s also the most niche — fewer user reports exist because it’s expensive and the effects are preventive (you don’t “feel” protection, you just don’t get sick). For brain health, heart protection, and metabolic support, Humanin has a loyal following among serious longevity biohackers.

Why People Are Interested

• Protects brain cells from degeneration. Humanin directly blocks the toxicity of amyloid beta (the protein that accumulates in Alzheimer’s) — it’s one of the few peptides with targeted neuroprotective data.
• Guards the heart and cardiovascular system. Protects heart cells during oxygen deprivation (heart attack, stroke models), reducing damage and improving recovery.
• Improves insulin sensitivity and metabolism. Helps pancreatic beta cells survive and function better — particularly interesting for diabetes research.
• Extends healthspan in animal models. Humanin levels decline with age. Restoring levels in research animals extends healthy lifespan through improved mitochondrial function.

Popular Combinations

• Humanin + SS-31 + MOTS-C: The mitochondrial trifecta — repair (SS-31), protect (Humanin), boost (MOTS-C). The most comprehensive mitochondrial protocol in existence.
• Humanin + NAD+: Complementary cellular protection and energy support.

⚠️ Sourced from public forums (Reddit r/Peptides, r/Biohackers, r/Longevity), biohacking blogs, and clinical research. Humanin has significantly fewer user experience reports than SS-31 or MOTS-C due to cost and niche appeal. There is a community-noted conflict: Humanin and MOTS-C both activate AMPK, which can lower IGF-1 — potentially conflicting with GH secretagogue protocols. Community protocols are experimental. This information is for awareness only.