LL-37

LL-37 (Cathelicidin) is the only human member of the cathelicidin family of antimicrobial peptides — naturally produced by immune cells, skin cells, and epithelial tissues. It serves as a first-line defense against bacteria, viruses, and fungi while also promoting wound healing and immune regulation. Supplied as lyophilized powder with ≥98% purity (HPLC-verified).

How It Works

LL-37 kills microbes by disrupting their cell membranes — a physical mechanism that works against bacteria, viruses including herpes and influenza, fungi, and even some parasites. Unlike antibiotics, this mechanical action makes resistance development extremely difficult. Beyond antimicrobial activity, LL-37 also activates wound healing pathways and modulates the immune response.

Research Data

• Broad-spectrum antimicrobial: Active against Gram-positive and Gram-negative bacteria (including MRSA and other antibiotic-resistant strains), enveloped viruses, and Candida species. Research shows rapid microbial killing within minutes of contact.
• Wound healing: Stimulates keratinocyte and fibroblast migration, promotes angiogenesis at wound sites, and accelerates re-epithelialization. Research shows significantly faster wound closure in treated vs untreated models.
• Immune modulation: Attracts immune cells to infection sites (chemotaxis), modulates cytokine production, and helps balance the inflammatory response — preventing both under-response (infection) and over-response (tissue damage).
• Biofilm disruption: Effective against bacterial biofilms — communities of bacteria protected by a slime matrix that are resistant to conventional antibiotics.
• LL-37 deficiency: Low LL-37 levels are linked to increased infection susceptibility, poor wound healing, and certain skin conditions including atopic dermatitis and psoriasis — making it a target for replacement therapy research.
• Anti-cancer potential: Emerging research suggests LL-37 may have selective anti-tumor activity in certain cancer types while preserving normal cells.
• Oral health: Naturally abundant in saliva and gingival tissue, LL-37 is investigated for periodontal disease and oral infection research.

Research Applications

• Antimicrobial peptide pharmacology
• Wound healing and tissue regeneration
• Innate immunity and host defense peptides
• Biofilm and antibiotic resistance research

Product Specifications

• Purity: ≥98% (HPLC)
• Form: Lyophilized powder
• Molecular Weight: ~4,493 Da
• Solubility: Reconstitute in sterile bacteriostatic water

Storage & Handling

• Store lyophilized peptide at -20°C, protected from light and moisture.
• After reconstitution, aliquot and store at -20°C. Avoid repeated freeze-thaw cycles.

Disclaimer: This product is intended exclusively for laboratory and research purposes. It is not a drug, dietary supplement, or food product. Not for human or veterinary use.

What the Internet Says

This is what online communities discuss. Not medical advice — for laboratory research use only.

Community Buzz

LL-37 is “nature’s antibiotic” — a cathelicidin antimicrobial peptide that your own body produces. It fights bacteria, viruses, fungi, and biofilms — broad-spectrum defense without the antibiotic resistance concerns of pharmaceuticals. The community uses it for chronic infections (Lyme, Babesia), gut dysbiosis, and stubborn wounds. Users report dramatic improvements: food allergies disappearing, chronic sinus infections clearing. One caution: users with psoriasis should be aware LL-37 is elevated in psoriatic skin and may theoretically worsen it — the community recommends pairing with KPV to counter inflammatory cytokine responses. Often stacked with Thymosin Alpha-1 for comprehensive immune protocols.

Why People Are Interested

• Fights everything — bacteria, viruses, fungi, biofilms. Broad-spectrum antimicrobial without antibiotic resistance concerns.
• Chronic infections that resisted everything finally respond. Lyme, gut dysbiosis, recurring sinus issues — frequently cited.
• Promotes wound healing and tissue repair. Beyond antimicrobial effects, LL-37 stimulates angiogenesis and wound closure.

⚠️ May worsen psoriasis in susceptible individuals. Community protocols are experimental. This information is for awareness only.