o-PCP EU

o-PCP (2-Keto-Phencyclidine): A Next-Gen Dissociative for Advanced Neurochemical Research

🧬 What is o-PCP?

o-PCP, short for ortho-Phencyclidine or 2-keto-PCP, is a novel arylcyclohexylamine dissociative, chemically related to PCP and 3-MeO-PCP. It features a ketone group at the ortho (2-) position on the cyclohexyl ring, setting it apart in both structure and receptor binding affinity.

Like other compounds in this class, o-PCP acts primarily as a non-competitive NMDA receptor antagonist, interrupting glutamatergic neurotransmission and producing effects ranging from analgesia and sedation to detachment and sensory alteration.

🧪 Chemical and Structural Details

• Full Name: 1-[1-(2-Oxocyclohexyl)phenyl]piperidine

• Molecular Formula: C17H23NO

• Molecular Weight: 257.37 g/mol

• CAS Number: Unregistered (as of 2025)

• Chemical Class: Arylcyclohexylamine

• Form: Typically crystalline powder or fine solid

The defining feature is its 2-keto substitution, which may affect receptor binding kinetics, lipid solubility, and psychoactive duration when compared with 3-MeO-PCP or ketamine.

⚙️ Mechanism of Action

o-PCP acts as a potent NMDA receptor antagonist, binding non-competitively to the PCP site on the NMDA ion channel. This disrupts calcium ion flow and inhibits excitatory glutamatergic signaling, resulting in:

• Disassociation from self and surroundings

• Analgesia and anesthesia

• Cognitive disruption

• Altered sensory integration

This compound may also interact with dopamine, serotonin, or sigma receptors to a minor extent, though these interactions are not well-characterized.

📊 Effects Profile (Based on Analogs)