o-PCP EU
Price range: €35.00 through €240.00
o-PCP (2-Keto-Phencyclidine): A Next-Gen Dissociative for Advanced Neurochemical Research
🧬 What is o-PCP?
o-PCP, short for ortho-Phencyclidine or 2-keto-PCP, is a novel arylcyclohexylamine dissociative, chemically related to PCP and 3-MeO-PCP. It features a ketone group at the ortho (2-) position on the cyclohexyl ring, setting it apart in both structure and receptor binding affinity.
Like other compounds in this class, o-PCP acts primarily as a non-competitive NMDA receptor antagonist, interrupting glutamatergic neurotransmission and producing effects ranging from analgesia and sedation to detachment and sensory alteration.
🧪 Chemical and Structural Details
Full Name: 1-[1-(2-Oxocyclohexyl)phenyl]piperidine
Molecular Formula: C17H23NO
Molecular Weight: 257.37 g/mol
CAS Number: Unregistered (as of 2025)
Chemical Class: Arylcyclohexylamine
Form: Typically crystalline powder or fine solid
The defining feature is its 2-keto substitution, which may affect receptor binding kinetics, lipid solubility, and psychoactive duration when compared with 3-MeO-PCP or ketamine.
⚙️ Mechanism of Action
o-PCP acts as a potent NMDA receptor antagonist, binding non-competitively to the PCP site on the NMDA ion channel. This disrupts calcium ion flow and inhibits excitatory glutamatergic signaling, resulting in:
Disassociation from self and surroundings
Analgesia and anesthesia
Cognitive disruption
Altered sensory integration
This compound may also interact with dopamine, serotonin, or sigma receptors to a minor extent, though these interactions are not well-characterized.
📊 Effects Profile (Based on Analogs)
| Domain | Effects |
|---|---|
| Physical | Numbness, motor impairment, anesthesia |
| Cognitive | Dissociation, amnesia, confusion |
| Sensory | Visual distortions, tinnitus, time dilation |
| Emotional | Euphoria, detachment, paranoia (at high doses) |
| Quantity |
500mg ,1g ,5g |
|---|
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