PNC-27
Price range: €500.00 through €880.00
PNC-27 is an anticancer peptide derived from the p53 tumor suppressor protein — the body’s most important defense against cancer. It selectively binds to cancer cells and forms pores in their membranes, causing rapid cell death, while leaving healthy cells untouched. Supplied as lyophilized powder with ≥98% purity (HPLC-verified).
How It Works
Cancer cells express high levels of HDM2 protein on their surface — much higher than healthy cells. PNC-27 binds specifically to HDM2 and then inserts itself into the cancer cell membrane, forming lethal pores. This causes rapid necrosis — the cancer cell literally bursts. Healthy cells don’t express enough HDM2 for PNC-27 to bind, so they are spared.
Research Data
- Selective cancer killing: Research shows PNC-27 kills a wide range of cancer cell lines — including pancreatic, breast, lung, leukemia, and melanoma — while showing minimal toxicity to normal cells.
- Membrane disruption: Unlike chemotherapy that works inside cells, PNC-27 kills cancer cells from the outside by physically disrupting their membranes — a mechanism cancer cells cannot easily develop resistance to.
- Tumor regression: Animal studies show significant tumor regression or complete remission in treated groups, with particular effectiveness in aggressive and chemotherapy-resistant cancers.
- p53-independent: Since PNC-27 works through membrane disruption rather than inside the cell, it kills cancer cells regardless of their p53 mutation status — including cancers that are resistant to p53-based therapies.
- HDM2 targeting: HDM2 is overexpressed in most human cancers but low in normal tissue — providing the selectivity that makes PNC-27 such a promising research tool.
- Combination potential: Research suggests PNC-27 may work synergistically with conventional chemotherapy, particularly in resistant tumors.
Research Applications
- Cancer biology and tumor cell membrane targeting
- p53/HDM2 pathway and apoptosis research
- Anticancer peptide pharmacology
- Chemotherapy resistance models
Product Specifications
- Purity: ≥98% (HPLC)
- Form: Lyophilized powder
- Solubility: Reconstitute in sterile bacteriostatic water
Storage & Handling
- Store lyophilized peptide at -20°C, protected from light and moisture.
- After reconstitution, aliquot and store at -20°C. Avoid repeated freeze-thaw cycles.
Disclaimer: This product is intended exclusively for laboratory and research purposes. It is not a drug, dietary supplement, or food product. Not for human or veterinary use.
What the Internet Says
This is what online communities discuss. Not medical advice — for laboratory research use only.
Community Buzz
PNC-27 is one of the most specialized and least discussed compounds in the peptide space — a cancer-research peptide that targets p53/HDM-2 interaction to selectively induce necrosis in malignant cells. Community discussion is near-zero; this is strictly an oncology research tool. The ability to cross the blood-brain barrier makes it theoretically relevant for brain cancers (glioma), but no community protocols or lay-user experience reports exist. This is laboratory research, not biohacking.
Why People Are Interested
- Selectively targets cancer cells. Binds to p53/HDM-2 complex to induce tumor cell necrosis.
- Crosses the blood-brain barrier. Potential relevance for brain cancer research.
⚠️ Strictly oncology research. Zero community experience reports. Not a biohacking compound. This information is for awareness only.
| Dosage |
10mg*10vials ,5mg*10vials |
|---|
Shipping & Delivery
All peptide products are shipped directly from our fulfillment center in China.
Delivery Time: 6 to 12 business days worldwide.
Tracking: A tracking number is provided via email once your order has been dispatched.
For any questions regarding your shipment, please contact our support team.
All peptide products are supplied as a lyophilized (freeze-dried) powder in sterile glass vials. Lyophilization preserves the peptide's structural integrity and biological activity during transport and storage. The powder must be reconstituted with an appropriate solvent before use in research protocols.
Recommended Solvent
For most peptide research applications, we recommend using Bacteriostatic Water (BAC) — sterile water containing 0.9% benzyl alcohol as a bacteriostatic agent. BAC water helps maintain sterility after reconstitution and is suitable for multi-dose research protocols.
Order Bacteriostatic Water (BAC) →
Reconstitution Protocol
- Prepare: Clean your work surface and ensure all materials (vial, BAC water, syringes) are handled in a sterile manner.
- Calculate: Determine the desired concentration by dividing the peptide mass (mg) by the volume of BAC water added (mL). For example, adding 2 mL of BAC water to a 5 mg vial yields a concentration of 2.5 mg/mL.
- Reconstitute: Using a sterile syringe, draw the calculated volume of BAC water. Insert the needle through the rubber stopper at an angle and slowly inject the solvent down the inner wall of the vial — avoid directing the stream directly onto the powder to prevent foaming.
- Dissolve: Gently swirl the vial (do not shake) until the powder is fully dissolved. Most peptides dissolve within 1-2 minutes. A clear, colorless solution indicates complete dissolution.
- Aliquot: For long-term use, transfer the reconstituted solution into sterile aliquots to avoid repeated freeze-thaw cycles of the original vial.
Post-Reconstitution Storage
- Store reconstituted peptide solution at 2-8°C for short-term use (up to 7 days).
- For extended storage, aliquot and freeze at -20°C. Avoid repeated freeze-thaw cycles.
- Always label aliquots with peptide name, concentration, date, and storage conditions.
Note: The optimal solvent and reconstitution protocol may vary depending on the specific peptide and research application. Researchers should consult peptide-specific literature for solubility guidance.
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We maintain strict quality control standards with third-party laboratory verification for every batch. Our lyophilized peptides are packaged under controlled conditions to ensure stability during shipping and storage. Detailed reconstitution and handling information is provided with every product to support accurate laboratory research protocols.
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